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1Immune Disease Institute and Department of Anesthesia, Harvard Medical School, Boston, Massachusetts 02115, USA; 2HST Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA; 3Harvard-MIT Division of Health Sciences and echnology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; 4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; 5Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; 6Department of Biochemistry, George S. Wise Faculty of Life Sciences, and the Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 69978, Israel +These authors contributed equally to this review