Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2 

 -  Journal of Controlled Release, 134(2), p.111-117, 2009 .
<br/><br/> It is advantageous to incorporate controlled growth factor delivery into tissue engineering strategies. The purpose of the present study was to develop a novel tissue engineering scaffold with the capability of controlled releasing BMP-2-derived synthetic peptide. Porous nano-hydroxyapatite/collagen/poly(L-lactic acid)/chitosan microspheres (nHAC/PLLA/CMs)composite scaffolds containing different quantities of chitosan microspheres (CMs)were prepared by a thermally induced phase separation method. Dioxane was used as the solvent for PLLA. Introduction of less than 30 
<br/><br/><label>Subjects--Topical Terms: </label><br/>POLY(L-LACTIC ACID)<br/>CHITOSAN<br/>NANO-HYDROXYAPATITE/COLLAGEN (NHAC)<br/>SYNTHETIC PEPTIDE<br/>TISSUE ENGINEERING<br/>CONTROLLED DELIVERY