TY  - BOOK
AU  - Landin,M.
AU  - York,P.
AU  - Cliff,M.J.
AU  - Rowe,R.C.
AU  - Wigmore,A.J.
TI  - Scale-up of a pharmaceutical granulation in fixed bowl mixer-granulators
KW  - GRANULATION
KW  - MIXER GRANULATORS
KW  - SCALE-UP
N2  - Scale-up in fixed bowl mixer-granulators has been studied by applying the classical dimensionless numbers of Power, Reynolds and Froude to end-point prediction in a range of geometrically similar machines. The simple relationship of Power number/Reynolds number, as suggested by previous workers, has been found to be nappropriate for large-scale production machines where corrections have to be made for gross vortexing and powder bed height variation by the incorporation of the Froude number and a scaling factor. When corrections are made, data from 25-, 100- and 600-1 machines all fall on the same curve allowing predictions of optimum granulation end-point conditions to be made for production-scale equipment from measurements on laboratory-scale equipment and vice-versa
UR  - https://drive.google.com/file/d/1vvguDzaJTI19g8n1JPJrhEwPVrF3zQIf/view?usp=drivesdk
ER  -