Verticilide, a new ryanodine-binding inhibitor, produced byVerticilliumsp. FKI-1033 

 -  The Journal of Antibiotics , 63(2), p.77-82, 2010 .
<br/><br/> A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus,Verticilliumsp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl-L-alanyl]4. Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC50value of 4.2lM, whereas inhibition against mouse ryanodine receptors was weak (IC50¼53.9lM). 
<br/><br/><label>Subjects--Topical Terms: </label><br/>DEPSIPEPTIDEINSECTICIDE<br/>RYANODINE-BINDING INHIBITOR<br/>RYANODINE RECEPTOR<br/>VERTICILIDE<br/>VERTICILLIUM