TY  - BOOK
AU  - Kazuro Shiomi
AU  - Ryosuke Matsui
AU  - Atsuo Kakei
AU  - Yuichi Yamaguchi
AU  - Rokuro Masuma
AU  - Hiroko Hatano
AU  - Noriko Arai
AU  - Noriko Arai
AU  - Haruo Tanaka
AU  - Susumu Kobayashi
AU  - Andreas Turberg
AU  - Satoshi Omura
TI  - Verticilide, a new ryanodine-binding inhibitor, produced byVerticilliumsp. FKI-1033
KW  - DEPSIPEPTIDEINSECTICIDE
KW  - RYANODINE-BINDING INHIBITOR
KW  - RYANODINE RECEPTOR
KW  - VERTICILIDE
KW  - VERTICILLIUM
N2  - A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus,Verticilliumsp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl-L-alanyl]4. Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC50value of 4.2lM, whereas inhibition against mouse ryanodine receptors was weak (IC50¼53.9lM)
UR  - https://drive.google.com/file/d/1rMZvRk8qCBc0AJs-B86_1FrULqPSBGyw/view?usp=drivesdk
ER  -