The antiviral activity of compounds isolated from Kenyan Carissa edulis (Forssk.)Vahl 

 -  Journal of Medicinal Plants Research, 4(15), p.1517-1522, 2010 .
<br/><br/> Extracts of a Kenyan medicinal plant, Carissa edulis (Forssk.)Vahl, were subjected to bioactivity guided phytochemical analysis for identification of biological makers of activity. Pure compounds; lupeol, oleuropein, carissol and ß-amyrin were subsequently isolated. In vitroevaluations of the compounds against viral strains of Herpes simples virustypes 1 revealed a significant activity for lupeolat EC 50 of between 2.98 - 4.2 µg/ml for both sensitive and resistant strains with a high therapeutic index (TI > 38). A concentration of the compound at 10.0 µg/ml was virucidal, reducing viral yields in Vero E6 cells by 98.3 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ANTIVIRAL ACTIVITY<br/>LUPEOL<br/>CARISSA EDULIS<br/>HERPES SIMPLEXVIRUS