TY  - BOOK
AU  - Tolo,F.M.
AU  - Rukunga,G.W.
AU  - Muli,F.W.
AU  - Ochora,J.M.
AU  - Irungu,B.N.
AU  - Muthaura,C.N.
AU  - Wanjiku,C.K.
AU  - Wanjiku,C.K.
AU  - Ngoc,Q.
AU  - Hashimoto,K.
AU  - Asakawa,Y.
TI  - The antiviral activity of compounds isolated from Kenyan Carissa edulis (Forssk.)Vahl
KW  - ANTIVIRAL ACTIVITY
KW  - LUPEOL
KW  - CARISSA EDULIS
KW  - HERPES SIMPLEXVIRUS
N2  - Extracts of a Kenyan medicinal plant, Carissa edulis (Forssk.)Vahl, were subjected to bioactivity guided phytochemical analysis for identification of biological makers of activity. Pure compounds; lupeol, oleuropein, carissol and ß-amyrin were subsequently isolated. In vitroevaluations of the compounds against viral strains of Herpes simples virustypes 1 revealed a significant activity for lupeolat EC 50 of between 2.98 - 4.2 µg/ml for both sensitive and resistant strains with a high therapeutic index (TI > 38). A concentration of the compound at 10.0 µg/ml was virucidal, reducing viral yields in Vero E6 cells by 98.3
UR  - https://drive.google.com/file/d/1FOkO3sSXWVxDDHoc3PHAfVTrVIaMsRvo/view?usp=drivesdk
ER  -