TY  - BOOK
AU  - Constabeli,F.
AU  - Rambow,S.
AU  - Shyluk,P.
AU  - Letourneau,D.
AU  - W.G.W.Kurz
AU  - Kutney,P.
TI  - Alkaloid Production in Catharanthus rose us Cell Cultures X. Mitotoxic Effect of 3',4'-Dehydrovinblastine
KW  - CATHARANTHUS ROSEUS
KW  - CELL CULTURE
KW  - PROTOPLASTS
KW  - 3; 4'·DEHYDROVINBLASTINE
KW  - MITOTOXICITY
N2  - Cells of established callus and suspension cultures derived from anther walls of periwinkle, Catharanthus Toseus (L.)G. Don, responded to 0.2 x 10-3 M 3',4'-dehydrovinblastine (dVBL)and vincristine with C-mitosis. Cells derived from protoplasts of periwinkle leaves and cultured for 3 weeks tolerated treatment with dVBL. The frequency of C-mitosis increased significantly as, over several weeks, protoplast derivatives continued to multiply and became callus cells, and in the presence of 5 x 10 -3 M dVBL. The effect of vincristine was similar to that of dVBL. Vin-doline and catharanthine, monomeric moieties of dVBL, did not exen mitotoxicity
UR  - https://drive.google.com/file/d/15_opd2szjNfyQfD4Y4litLksBctYk4Ae/view?usp=drivesdk
ER  -