TY  - BOOK
AU  - Burgess,R.R.
TI  - Chapter 3 Use of Bioinformatics in Planning a Protein Purification
KW  - AMINO ACID SEQUENCE
KW  - BIOINFORMATICS
KW  - ENZYMOLOGY
KW  - GENE SEQUENCE
KW  - GENOME
KW  - PRIORITY JOURNAL
KW  - PROTEIN ANALYSIS
KW  - PROTEIN PURIFICATION
KW  - PROTEIN STRUCTURE
KW  - REVIEW
KW  - ALGORITHM
KW  - ANIMAL
KW  - BIOLOGY
KW  - CHEMISTRY
KW  - HUMAN
KW  - METABOLISM
KW  - METHODOLOGY
KW  - PHYSIOLOGY
KW  - PROTEIN CONFORMATION
KW  - PROTEIN DENATURATION
KW  - PROTEIN MULTIMERIZATION
KW  - PROTEIN PROCESSING
N2  - Now that many hundreds and even thousands of whole genomes have been sequenced, it is rare to be studying a target protein whose amino acid sequence is not known. However, it is still often necessary to obtain large amounts of the target protein for a variety of purposes including structural studies, drug discovery, enzymology, protein biochemistry, and industrial application. It would seem that knowing the amino acid sequences would make it much easier to design an effective purification of that protein. We examine in this chapter what you can and cannot predict from an amino acid sequence and conclude that protein purification is still largely an empirical science. © 2009 Elsevier Inc. All rights reserved
UR  - https://drive.google.com/file/d/1oEkyjn6sC45wtg-j_AAv9ItyCreSafl3/view?usp=drivesdk
ER  -