TY  - BOOK
AU  - Rogne,M.
AU  - Tasken,K.
TI  - Compartmentalization of cAMP signaling in adipogenesis, lipogenesis, and lipolysis
KW  - YCLIC AMP
KW  - CYCLIC AMP DEPENDENT PROTEIN KINASE
KW  - CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN
KW  - CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN
KW  - FAT DROPLET
KW  - HORMONE SENSITIVE LIPASE
KW  - PERILIPIN
KW  - PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
KW  - TRIACYLGLYCEROL LIPASE
KW  - CYCLIC AMP
N2  - Energy storage and release at times of food excess or fasting are carefully coordinated processes that depend on the appropriate differentiation of mesenchymal stem cells into mature adipocytes (adipogenesis)forming white adipose tissue (WAT)and on regulatory signals for storage (lipogenesis)or mobilization (lipolysis)of triacylglycerides (TAGs)from lipid droplets. It is widely recognized that cAMP signaling via protein kinase A (PKA)is important both in adipogenesis and for hormonal control and lipolysis in WAT. A kinase anchoring proteins (AKAPs)target PKA to distinct subcellular compartments in close proximity to its specific substrates thereby providing spatial and temporal specificity in the mediation of biological effects controlled by the cAMP-PKA pathway. This review will provide an updated overview of some of the sites of regulation by cAMP in adipogenesis and lipolysis and the involvement of AKAPs and highlighting, as a recent example, the AKAP Optical Atrophy 1 (OPA1)and its role in the phosphorylation of Perilipin to induce lipolysis
UR  - https://drive.google.com/file/d/1QN6Vr-TExJ1jz7lQrSMrhZetVTjdrsJg/view?usp=drivesdk
ER  -