TY - BOOK AU - Licatalosi,D.D. AU - Darnell,R.B. TI - RNA processing and its regulation: Global insights into biological networks KW - ALTERNATIVE SPLICING KW - ANIMALS KW - COMPUTATIONAL BIOLOGY KW - GENE EXPRESSION PROFILING KW - GENE EXPRESSION REGULATION KW - GENE REGULATORY NETWORKS KW - GENETIC VARIATION KW - HUMANS KW - MODELS, BIOLOGICAL KW - MODELS, GENETIC KW - OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS KW - POLYADENYLATION KW - RNA KW - RNA EDITING KW - TRANSCRIPTION, GENETIC N2 - In recent years views of eukaryotic gene expression have been transformed by the finding that enormous diversity can be generated at the RNA level. Advances in technologies for characterizing RNA populations are revealing increasingly complete descriptions of RNA regulation and complexity; for example, through alternative splicing, alternative polyadenylation and RNA editing. New biochemical strategies to map protein-RNA interactions in vivo are yielding transcriptome-wide insights into mechanisms of RNA processing. These advances, combined with bioinformatics and genetic validation, are leading to the generation of functional RNA maps that reveal the rules underlying RNA regulation and networks of biologically coherent transcripts. Together these are providing new insights into molecular cell biology and disease. © 2010 Macmillan Publishers Limited. All rights reserved UR - https://drive.google.com/file/d/1B-2JW2RDud5DQuS9ryMq4ZGT0hxWTPeY/view?usp=drivesdk ER -