TY  - BOOK
AU  - Dineshkumar,B.
AU  - Mitra,A.
AU  - Manjunatha,M.
TI  - Studies on the anti-diabetic and hypolipidemic potentials of mangiferin (xanthone glucoside)in streptozotocin-induced type 1 and type 2 diabetic model rats
KW  - ACARBOSE
KW  - ALPHA GLUCOSIDASE
KW  - AMYLASE
KW  - CHOLESTEROL
KW  - GLIBENCLAMIDE
KW  - GLUCOSE
KW  - HIGH DENSITY LIPOPROTEIN
KW  - LOW DENSITY LIPOPROTEIN
KW  - MANGIFERIN
KW  - RECOMBINANT HUMAN INSULIN
KW  - TRIACYLGLYCEROL
KW  - VERY LOW DENSITY LIPOPROTEIN
N2  - Context: Mangifera indica (Anacardiaceae)stem bark contains a rich content of mangiferin and is used traditionally in Indian Ayurvedic system to treat diabetes. Purpose of the study: To investigate anti-diabetic and hypolipidemic effects of mangiferin in type 1 and type 2 diabetic rats models. Streptozotocin was used to induce type 1 and type 2 diabetic rats. Mangiferin (at a dose 10 and 20mg/kg)was administrated intra-peritoneally in type 1 and type 2 diabetic rats daily up to 30 days. Biochemical parameters notably fasting blood sugar, total cholesterol, triglycerides, low-density lipoprotein, very low-density lipoprotein and high-density lipoprotein were estimated. In addition, in vitro alpha amylase and alpha glucosidase inhibitory effects of mangiferin were performed and IC50 values were determined. Results: Mangiferin exhibited significant (P<0.05)anti-diabetic as well as hypolipidemic effects by lowering FBS, TC, TG, LDL, and VLDL levels; but also with elevation of HDL level in type 2 diabetic model rats. In addition, mangiferin showed appreciable alpha amylase inhibitory effect (IC50 value 74.35±1.9µg/ml)and alpha glucosidase inhibitory effect (IC50 41.88±3.9µg/ml)when compared with standard drug acarbose (IC50 83.33±1.2µg/ml). Conclusions: Mangiferin showed anti-diabetic as well as hypolipidemic potentials in type 2 diabetic model rats. Therefore, mangiferin possess beneficial effects in the management of type 2 diabetes with hyperlipidemia
UR  - https://drive.google.com/file/d/1YBVh_YImOjysnrcv5Uq2IlibednqnKl1/view?usp=drivesdk
ER  -