TY  - BOOK
AU  - Zischler,H.
AU  - Geisert,H.
AU  - Von Haeseler,A.
AU  - Pääbo,S.
TI  - A nuclear 'fossil' of the mitochondrial d-loop and the origin of modern humans
KW  - ANIMAL
KW  - BASE SEQUENCE
KW  - CHROMOSOMES, HUMAN, PAIR 11
KW  - DNA, MITOCHONDRIAL
KW  - EVOLUTION, MOLECULAR
KW  - HOMINIDAE
KW  - HUMAN
KW  - MALE
KW  - MOLECULAR SEQUENCE DATA
KW  - PAN TROGLODYTES
KW  - POLYMERASE CHAIN REACTION
KW  - PSEUDOGENES
KW  - RECOMBINATION, GENETIC
KW  - SPERM HEAD
N2  - Mammalian mitochondria! DNA sequences evolve more rapidly than nuclear sequences1. Although the rapid rate of evolution is an advantage for the study of closely related species and populations, it presents a problem in situations where related species, used as outgroups in phylogenetic analyses, have accumulated so much change that multiple substitutions obliterate the phylogenetic information2. However, mitochondrial DNA sequences are frequently inserted into the nuclear genome3, where they presumably evolve as nuclear pseudogene sequences and therefore more slowly than their mitochondria! counterparts. Such sequences thus represent molecular 'fossils' that could shed light on the evolution of the mitochondrial genome and could be used as outgroups in situations where no appropriate outgroup species exist. Here we show that human chromosome 11 carries a recent integration of the mitochondrial control region that can be used to gain further insight into the origin of the human mitochondrial gene pool. © 1995 Nature Publishing Group. All rights reserved
UR  - https://drive.google.com/file/d/1RouaWR15e7Tip1-Gs2iYkTtix42Ti8bp/view?usp=drivesdk
ER  -