TY  - BOOK
AU  - Saze,H.
AU  - Scheid,O.M.
AU  - Paszkowski,J.
TI  - Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis
KW  - ARABIDOPSIS
KW  - ARTICLE
KW  - CHROMATIN
KW  - CONTROLLED STUDY
KW  - CPG ISLAND
KW  - DEMETHYLATION
KW  - DNA METHYLATION
KW  - DNA MODIFICATION
KW  - DNA REPLICATION
KW  - FERTILIZATION
KW  - GAMETOGENESIS
KW  - GENE FUNCTION
KW  - GENE MUTATION
KW  - GENETIC VARIABILITY
KW  - HAPLOIDY
KW  - MEIOSIS
KW  - NONHUMAN
KW  - NUCLEOTIDE SEQUENCE
KW  - PRIORITY JOURNAL
KW  - PROTEIN SYNTHESIS
KW  - RECESSIVE INHERITANCE
KW  - SEQUENCE ANALYSIS
KW  - SEQUENCE HOMOLOGY
KW  - ZYGOTE
N2  - In mammals, the DNA methyltransferase 1 (Dnmt1)faithfully copies the pattern of cytosine methylation at CpG sites to the newly synthesized strand, and this is essential for epigenetic inheritance1. In Arabidopsis thaliana, several DNA methyltransferases or chromatin modifiers coupled to methylation changes have been characterized, and mutations that cause loss of their function are recessive2-7. This is surprising because plant gametogenesis includes postmeiotic DNA replication in haploid nuclei before fertilization. Therefore, the recessive character of the mutations excludes the affected components from a regulatory role in postmeiotic maintenance or modification of epigenetic states. Here we show, however, that depletion of A. thaliana MET1, a homolog of mammalian Dnmt1 (ref. 8), results in immense epigenetic diversification of gametes. This diversity seems to be a consequence of passive postmeiotic demethylation, leading to gametes with fully demethylated and hemidemethylated DNA, followed by remethylation of hemimethylated templates once MET1 is again supplied in a zygote
UR  - https://drive.google.com/file/d/1oFmmyXEV4XcpJOVmL7LWZIrVZ_j87elg/view?usp=drivesdk
ER  -