Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991 

 -  Journal of Antibiotics, 69(2), p.89-96, 2016 .
<br/><br/> Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis. © 2016 Japan Antibiotics Research Association. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>BACILLUS SUBTILIS<br/>CHEMICAL STRUCTURE<br/>CHEMISTRY<br/>CULTURE MEDIUM<br/>DISK DIFFUSION<br/>DRUG EFFECTS<br/>EMERICELLA<br/>GROWTH, DEVELOPMENT AND AGING<br/>HUMAN<br/>ISOLATION AND PURIFICATION<br/>METABOLISM<br/>NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY