TY  - BOOK
AU  - Jones,P.A.
TI  - Functions of DNA methylation: Islands, start sites, gene bodies and beyond
KW  - CÁNCER
KW  - CELLCARCINOGENESIS
KW  - CPG ISLAND
KW  - DNA METHYLATION
KW  - EMBRYO DEVELOPMENT
KW  - GENE REPRESSION
KW  - GENE SILENCING
KW  - HUMAN
KW  - NONHUMAN
KW  - PRIORITY JOURNAL
KW  - PROTEIN BINDIN
KW  - GREGULATORY SEQUENCE
KW  - REVIEW
KW  - SEQUENCE ANALYSIS
KW  - TRANSCRIPTION INITIATION SITE
N2  - DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scale mapping of methylation, we can evaluate DNA methylation in different genomic contexts: transcriptional start sites with or without CpG islands, in gene bodies, at regulatory elements and at repeat sequences. The emerging picture is that the function of DNA methylation seems to vary with context, and the relationship between DNA methylation and transcription is more nuanced than we realized at first. Improving our understanding of the functions of DNA methylation is necessary for interpreting changes in this mark that are observed in diseases such as cancer. © 2012 Macmillan Publishers Limited. All rights reserved
UR  - https://drive.google.com/file/d/1r85Gi1Tl0XieUHUF-5AE8LsuEI2jtI4O/view?usp=drivesdk
ER  -