TY  - BOOK
AU  - Zhao Qh
AU  - Mcnally Ak
AU  - Rubin Kr
AU  - Renier M
AU  - Wu Y
AU  - Rose-Caprara V
AU  - Anderson Jm
AU  - Anderson Jm
AU  - Urbanski P
AU  - Stokes K
TI  - Human plasma alpha 2-macroglobulin promotes in vitro oxidative stress cracking of Pellethane 2363-80A: in vivo and in vitro correlations
KW  - PLASMA
N2  - It is hypothesized in this study that the phenomenon of environmental stress cracking (ESC)in polyetherurethane is caused by a synergistic action of biological components in the body fluids, oxidative agents, and stress. An in vitro system is designed to mimic the in vivo system; human plasma contains certain biological components that can act as a stress cracking promoter, while H2O2 (Co)solution provides an oxidative reaction comparable to that observed in the respiratory burst of adherent macrophages and foreign-body giant cells. It is demonstrated that the phenomenon of in vivo stress cracking in Pellethane 2363-80A is duplicated by an in vitro system that involves a pretreatment of prestressed specimens with human plasma at 37 degrees C for 7 days followed by oxidation in 10 percent hydrogen peroxide with 0.10M cobalt chloride at 50 degrees C for 10 days. The pretreatment with plasma has a synergistic effect with the oxidation by H2O2 (Co)treatment to produce ESC. A plasma component responsible for promoting stress cracking in Pellethane polyurethane is identified to be alpha 2-macroglobulin (alpha 2M)
UR  - https://drive.google.com/file/d/18xd-bV3KV9odW_y6b-bq6visYSHTpsmi/view?usp=drivesdk
ER  -