The expanding CRISPR-Cas toolbox
- Genetic Engineering and Biotechnology News, 38(11), p.S18-S20, 2018 .
Microbes are great teachers, and they never disappoint. Among the most recent things that we learned from bacteria and archaea is that they possess many defenses against environmental attacks such as those initiated by viruses. Bacteria, for example, make good use of an adaptive immune system called CRISPR-Cas. (CRISPR, or clustered regularly interspaced short palindromic repeats, refers to a characteristic pattern found in the DNA sequences of bacteria and archaea. Cas refers to CRISPR-associated endonucleases.)