TY  - BOOK
AU  - Chen,L.
AU  - Li,Y.P.
AU  - Li,X.X.
AU  - Lu,Z.H.
AU  - Zheng,Q.H.
AU  - Liu,Q.Y.
TI  - Isolation of 4, 4?-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma
KW  - FUNGUS
KW  - PENICILLIUM OXALICUM
KW  - CANCER
N2  - 4,4?-bond secalonic acid D (4,4?-SAD)is a known compound isolated from the marine-derived fungus Penicillium oxalicum. No study about the antitumor effect of this compound has been reported, except for a few focusing on its bactericidal properties. Herein, we performed an in vitro biology test and found that 4,4?-SAD stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines PLC/PRF/5 and HuH-7 by activating caspase-3, caspase-8, caspase-9, PARP, p53, and cyclin B1, as well as by regulating the Bax/Bcl-2 ratio. In vivo studies showed that 4,4?-SAD had antitumor efficacy in H22 cell xenograft model. Immunohistochemical analysis revealed that 4,4?-SAD could regulate Bax expression, which is a biomarker of tumor growth. In summary, 4,4?-SAD significantly inhibited tumor growth both in vivo and in vitro
UR  - https://drive.google.com/file/d/1brn43dCWkFGUjZ4cuV3N4qmbsUthrxRd/view?usp=drivesdk
ER  -