TY  - BOOK
AU  - Han,K.A.
AU  - Jeon,S.
AU  - Um,J.W.
AU  - Ko,J.
TI  - Emergent synapse organizers: LAR-RPTPs and their companions
KW  - LAR
KW  - PTP
KW  - SYNAPTIC ADHESIÓN
KW  - RECEPTOR PROTEIN TYROSINE PHOSPHATASE
KW  - LIGANDS
KW  - SYNAPSE DEVELOPMENT
KW  - ALTERNATIVE SPLICING
KW  - HEPARAN SULFATE
N2  - Leukocyte common antigen-related receptor tyrosine phosphatases (LAR-RPTPs)have emerged as key players that organize various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. Recent research has highlighted the roles of LAR-RPTPs at neuronal synapses in mediating distinct synaptic adhesion pathways through interactions with a host of extracellular ligands and in governing a variety of intracellular signaling cascades through binding to various scaffolds and signaling proteins. In this chapter, we review and update current research progress on the extracellular ligands of LAR-RPTPs, regulation of their extracellular interactions by alternative splicing and heparan sulfates, and their intracellular signaling machineries. In particular, we review structural insights on complexes of LAR-RPTPs with their various ligands. These studies lend support to general molecular mechanisms underlying LAR-RPTP-mediated synaptic adhesion and signaling pathways
UR  - https://drive.google.com/file/d/1Q983Q7D947AES_tK2wBMdgg6RElFgb2i/view?usp=drivesdk
ER  -