TY  - BOOK
AU  - Tang,P.
AU  - Lin,H.X.
AU  - Yuan,T.H.
AU  - Cui,Y.M.
TI  - Synthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI
KW  - 1-DEOXYBACCATIN VI
KW  - TAXANE
KW  - CYTOTOXICITY
KW  - OXIDATION
KW  - SYNTHESIS
N2  - our C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities
UR  - https://drive.google.com/file/d/13_-dOfCiQFwRqElhG1uxktUxkLUAN_6H/view?usp=drivesdk
ER  -