N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. 

 -  Science, 367(6477), p.580-586, 2020 .
<br/><br/> N6-methyladenosine (m6A)is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs)in mammalian cells. Disruption of m6A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>RNA REGULATES CHROMATIN<br/>TRANSCRIPTION