A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala. 

 -  Tetrahedron, 74(28), p.3852-3857, 2018 .
<br/><br/> Caesaldecins A and B (1a/1b), a pair of epimeric cassane-type diterpenoids containing an ether linkage between C-6 and C-20 and an ?,?-butenolide ring in the northern hemisphere, were isolated from the leaves of the medicinal plant Caesalpinia decapetala (Roth)Alston, along with a new labdane-type diterpenoid, termed as 8(17),11(Z),13(E)-trien-15,18-dioic acid (2). Structures of 1 and 2 were established by extensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR, and electronic circular dichroism (ECD)calculations. The in vitro antibacterial and inhibitory activities against a panel of bacteria and cancer cell lines were evaluated, respectively. Compound 2 displayed moderate antibacterial activity against the methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA)with an MIC50 value of 5.99??g?mL?1. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>CAESALPINIA DECAPETALA (ROTH)ALSTON<br/>CASSANE-TYPE FURANODITERPENOID<br/>MIXTURE OF EPIMERS<br/>ECD CALCULATIONS<br/>ANTIBACTERIAL ACTIVITIES