Bioactive cassane diterpenoids from the seeds of Caesalpinia sappan. 

 -  PhytoChemistry Letters, 22, p.113-116, 2017 .
<br/><br/> Three new cassane-type diterpenoids named caesalppans G-I (1-3)together with three known ones (4-6), were isolated from the methanol extract of Caesalpinia sappan seeds. Their structures were determined based on spectroscopic data. Among the isolated compounds, compound 2 displayed a moderate antimalarial activity with an IC50 value of 2.4 ?M, and compound 4 showed mild anti-inflammatory activity with an IC50 value of 28.65 ?M. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>CAESALPINIA SAPPAN<br/>CASSANE-TYPE DITERPENOID<br/>ANTIMALARIAL ACTIVITY<br/>ANTI-INFLAMMATORY ACTIVITIY