Glycol chitin-based thermoresponsive hydrogel scaffold supplemented with enamel matrix derivative promotes odontogenic differentiation of human dental pulp cells.
- Journal of endodontics,, 39(8), p.1001-1007., 2013 .
Hydrogels have been widely studied as tissue engineering scaffolds over the past 2 decades because of their favorable biological properties. Recently, a new biodegradable glycol chitin-based thermoresponsive hydrogel scaffold (GC-TRS)was developed that can be easily applied as a mild viscous solution at room temperature but quickly transforms into a durable hydrogel under physiological conditions. The aim of this study was to investigate the effects of GC-TRS on the proliferation and odontogenic differentiation of colony-forming human dental pulp cells (hDPCs)in the presence of enamel matrix derivative