TY  - BOOK
AU  - Musheev,M.U.
AU  - Baumgärtner,A.
AU  - Krebs,L.
AU  - Niehrs,C.
TI  - The origin of genomic N 6-methyl-deoxyadenosine in mammalian cells
N2  - The proposal that N6-methyl-deoxyadenosine (m6dA)acts as an epigenetic mark in mammals remains controversial. Using isotopic labeling coupled to ultrasensitive mass spectrometry, we confirm the presence of low-level m6dA in mammalian DNA. However, the bulk of genomic m6dA originates from ribo-N6-methyladenosine, which is processed via the nucleotide-salvage pathway and misincorporated by DNA polymerases. Our results argue against m6dA acting as a heritable, epigenetic DNA mark in mammalian cells
UR  - https://drive.google.com/file/d/1iS-MxnhZqutIsVt8Y2XVhJe8bPuv38ys/view?usp=drivesdk
ER  -