Isolation and biological activity of azocine and azocane alkaloids
- Bioorganic & Medicinal Chemistry, 54(116560), 2022 .
Thousands of known alkaloids contain a nitrogen (N)heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants)are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of alkaloids that contain an azocine (or saturated azocane)ring, and the array of sources whence they originate.