TY  - BOOK
AU  - Yu,X.
AU  - Gao,Y.
AU  - Frank,M.
AU  - Mándi,A.
AU  - Kurtán,T.
AU  - Müller,W.E.
AU  - Proksch,P.
TI  - Induction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach
KW  - ENDOPHYTIC FUNGUS
KW  - PESTALOTIOPSIS LESPEDEZAE
KW  - PESTALLIC ACIDS
KW  - IODINATED NATURAL PRODUCT
KW  - TDDFT-ECD
N2  - Ten new ambuic acid derivatives, pestallic acids H-Q including one new iodinated natural product along with two known compounds, ambuic acid and ambuic acid 18-acetate, were obtained through fermentation of the endophytic fungus Pestalotiopsis lespedezae on solid rice medium with 3.5 percent NaI. Pestallic acids H-Q were undetectable in cultures of the fungus grown on solid rice medium lacking NaI or in those where NaI had been replaced by NaCl or NaBr. The structures of the new metabolites were established on basis of 1D/2D NMR and HRESIMS data. Their absolute configurations were determined by Mosher's method and TDDFT-ECD calculations. The compounds failed to show antibacterial activity against S. aureus (ATCC29213), drug-resistant Acinetobacter baumannii (BAA1605)or Mycobacterium tuberculosis, as well as cytotoxicity against the mouse lymphoma cell line L5178Y
UR  - https://drive.google.com/file/d/1kIItIE2qmE5NNzn6gr-kzYXkm-sH8_U7/view?usp=drivesdk
ER  -