TY  - BOOK
AU  - Maekawa,T.
AU  - Kufer,T.A.
AU  - Schulze-Lefert,P.
TI  - NLR functions in plant and animal immune systems: so far and yet so close
N2  - In plants and animals, the NLR family of receptors perceives non-self and modified-self molecules inside host cells and mediates innate immune responses to microbial pathogens. Despite their similar biological functions and protein architecture, animal NLRs are normally activated by conserved microbe- or damage-associated molecular patterns, whereas plant NLRs typically detect strain-specific pathogen effectors. Plant NLRs recognize either the effector structure or effector-mediated modifications of host proteins. The latter indirect mechanism for the perception of non-self, as well as the within-species diversification of plant NLRs, maximize the capacity to recognize non-self through the use of a finite number of innate immunoreceptors. We discuss recent insights into NLR activation, signal initiation through the homotypic association of N-terminal domains and subcellular receptor dynamics in plants and compare those with NLR functions in animals
UR  - https://drive.google.com/file/d/1ZDDHX97aO7QjA_L4Z54wSReMraFYX5cf/view?usp=drivesdk
ER  -