TY  - BOOK
AU  - Ohizumi,H.
AU  - Masuda,Y.
AU  - Nakajo,S.
AU  - Sakai,I.
AU  - Ohsawa,S.
AU  - Nakaya,K.
TI  - Geranylgeraniol is a potent inducer of apoptosis in tumor cells
KW  - APOPTOSIS
KW  - GERANYLGERANIOL
KW  - ISOPRENOID
KW  - TUMOR CELL
N2  - We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM
UR  - https://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk
ER  -