TY - BOOK AU - Atwood III,J.A. AU - Weatherly,D.B. AU - Minning,T.A. AU - Bundy,B. AU - Cavola,C. AU - Opperdoes,F.R. AU - Tarleton,R.L. TI - The Trypanosoma cruzi proteome T2 - Science, 309(5733), p.473-476, 2005 N2 - To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identified across the four life-cycle stages. Protein products were identified from >1000 genes annotated as "hypothetical" in the sequenced genome, including members of a newly defined gene family annotated as mucin-associated surface proteins. The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes UR - https://drive.google.com/file/d/1n3_n9Yg5DKYqXo0wzVQPdeKYQXvj-DG3/view?usp=drive_link ER -