TY  - BOOK
AU  - Pacheco-Hernández,Y.
AU  - Rangel-Galván,M.
AU  - Velásquez-Hernández,F.E.
AU  - Lozoya-Gloria,E.
AU  - Castro-Juárez,C.J.
AU  - Villa-Ruano,N.
TI  - Chemical Variation and Biological Properties of the Essential Oil and Main Volatiles of Pimenta dioica Harvested in the Northern Highlands of Puebla, Mexico
T2  - Chemistry & Biodiversity, https://doi.org/10.1002/cbdv.202402843
KW  - ANTI-HELICOBACTER PYLORI
KW  - ANTI-LIPASE
KW  - BETA-MYRCENE
KW  - ESSENTIAL OIL
KW  - EUGENOL
KW  - PIMENTA DIOICA
N1  - Artículo
N2  - The chemical variation of the annual essential oils from Pimenta dioca (PdEOs) grown in the Northern Highlands of Puebla, Mexico, and their biological activities were determined. Eugenol (>50 percent) and beta-myrcene (>16 percent) were the main volatiles contained in the annual PdEOs (2022-2024) extracted from fruit and leaves. PdEOs showed inhibitory properties on human pancreatic lipase (IC50, 33-44 µg/mL) through mixed type inhibition with clear eugenol involvement (IC50, 47 µg/mL). The oral administration of PdEOs and eugenol combined with corn oil on ICR mice (p < 0.01), confirmed a strong anti-hypertriglyceridemic activity at 3 and 4.5 h post-treatment. PdEOs showed low toxicity in 3T3 fibroblasts and probiotics (IC50 >500 µg/mL), whereas high lethal dose in ICR mice (LD50 >8000 mg/kg BW). Eugenol, beta-myrcene and PdEOs decreased Helicobacter pylori viability acting as mixed inhibitors on urease. Results of anti-lipase and anti-H.pylori urease assays were endorsed by docking calculations
UR  - https://drive.google.com/file/d/1eYJSfqIQUz5YAheTmUTCYzw1KpBaT8UC/view?usp=drive_link
ER  -