TY  - BOOK
AU  - Sarker,P.
AU  - Sani,D.H.
AU  - Miah,M.F.
AU  - Alam,M.J.
TI  - Curbing Key Digestive Enzymes by Three Plant Extracts for Sustainable Management of Postprandial Hyperglycemia
T2  - Letters in Drug Design & Discovery, 21(11), p.2015-2022, 2024
KW  - DIABETES MELLITUS
KW  - POSTPRANDIAL HYPERGLYCEMIA
KW  - ANTIDIABETIC ACTIVITY
KW  - Α-AMYLASE
KW  - Α-GLUCOSIDASE
KW  - ACARBOSE
KW  - HYLOCEREUS POLYRHIZUS
KW  - BAMBUSA VULGARIS
KW  - BRASSICA RAPA L
N1  - Artículo
N2  - Abstract: Background: Diabetes mellitus is a chronic metabolic condition marked by persistently elevated blood sugar levels. Key digestive enzymes viz. α-amylase and α-glucosidase, hydrolyze consumed carbohydrates into glucose which raises the postprandial blood glucose level in a diabetic patient. So, the development of α-amylase and α-glucosidase inhibitors procured from medicinal plants to retard starch digestion is an alternative approach for controlling type 2 diabetes mellitus. Objective: The current study aimed to evaluate the inhibitory potentials of the key digestive enzymes viz. α-amylase and α-glucosidase by the extracts of three medicinal plants; red dragon fruit (Hylocereus polyrhizus) pulp and peel, bamboo (Bambusa vulgaris) shoot, turnip (Brassica rapa L.) shoot and leaf by performing α-amylase and α-glucosidase inhibition assays in vitro. Methods: Inhibition of α-amylase activity was conducted using 3,5-dinitrosalicylic acid method, and 4- Nitrophenyl-α-D-glucopyranoside was used as a substrate to perform α-glucosidase inhibition assay in vitro. Results: Among all the selected sample extracts, red dragon fruit pulp expressed the highest percentage of α-amylase inhibition (59.73 ± 4.33 percent) at the concentration of 1000 µg/mL which is comparable to standard antidiabetic drug Acarbose (70.59 ± 2.64 percent), whereas the lowest inhibition was observed in turnip shoot extract (42.48 ± 2.10 percent) at the same concentration. In terms of α-glucosidase inhibition activity, again, red dragon fruit pulp extract demonstrated the maximum inhibition rate (56.42 ± 2.38 percent) at 1000 µg/mL concentration. This is respectable in comparison to the reference Acarbose (66.45 ± 1.78 percent). In contrast, turnip shoot extracts displayed the lowest α-glucosidase inhibition activity (38.27 ± 2.21 percent) at the same concentration. Conclusion: The current study demonstrated that the red dragon fruit pulp extract possesses substantial antihyperglycemic activity (α-amylase inhibition: 59.73 ± 4.33 percent, α-glucosidase inhibition: 56.42 ± 2.38 percent) in vitro, which could be a putative nutraceutical to manage postprandial hyperglycemia
UR  - https://drive.google.com/file/d/1MnOLMWFrfafEBzcXqTiFHgZpiRAZrqCE/view?usp=drive_link
ER  -