TY  - BOOK
AU  - Rousset,F.
AU  - Osterman,I.
AU  - Scherf,T.
AU  - Falkovich,A.H.
AU  - Leavitt,A.
AU  - Amitai,G.
AU  - Sorek,R.
TI  - TIR signaling activates caspase-like immunity in bacteria
T2  - Science, 387(6733), 510-516, 2025 
N1  - Artículo
N2  - Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprising both a caspase-like protease and a TIR-domain protein. We found that the TIR protein, once it recognizes phage invasion, produces the previously unknown immune signaling molecule adenosine 5′-diphosphate-cyclo[N7:1′′]-ribose (N7-cADPR). This molecule specifically activates the bacterial caspase-like protease, which then indiscriminately degrades cellular proteins to halt phage replication. The TIR-caspase defense system, which we denote as type IV Thoeris, is abundant in bacteria and efficiently protects against phage propagation. Our study highlights the diversity of TIR-produced immune signaling molecules and demonstrates that cell death regulated by proteases of the caspase family is an ancient mechanism of innate immunity
UR  - https://drive.google.com/file/d/11sxSE5A98uTJoK2brLBXGJMy0IRS1sxU/view?usp=drive_link
ER  -