Textbook oxidative phosphorylation needs to be rewritten. 

 - Trends in Biochemical Sciences, 52(2), p.87-88, 2025 .
<br/><br/> Artículo 
<br/><br/> Oxidative phosphorylation (OxPhos) is the energy-transfer process that generates most of our ATP, fueled by proton and electrical gradients across the inner mitochondrial membrane. A new surprising finding by Hernansanz-Agustín et al. demonstrates that between one-third and half of this gradient is attributable to Na+, transported in exchange for protons within complex I. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>COMPLEX I<br/>ION TRANSPORT<br/>MITOCHONDRIA<br/>OXIDATIVE PHOSPHORYLATION<br/>SODIUM-PROTON EXCHANGE