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Biocompatibility of Polyurethane Urea Elastomers for Cardiac Tissue Engineering

Tipo de material: TextoTextoSeries ; Mater. Res. Soc. Symp. Proc, 1376, p.17-19, 2012Trabajos contenidos:
  • Paredes-Puerto, A
  • Dashti, D
  • Yeghiazarians, Y
  • Healy, K.E
  • Hernández-Sánchez, F
Recursos en línea: Resumen: Cardiac disease is the main cause of death in men and women in México and the U.S.A. When heart muscle suffers an injury, i.e. cardiac infarction, the tissue dies and is replaced by a fibrotic scar that does not allow for normal organ function. To alleviate scar tissue, the objective of this work was to investigate and synthesize polyurethane ureas from polycaprolactone diol, methylene bis(4-cyclohexilisocyanate), and butanediamine with different hard segment contents, characterize them, and prove their biocompatibility by seeding SCA-1+/CD45- cardiac progenitor cells obtained from mice cardiospheres. Ultimately, this work aims to explore how polyurethane urea elastomers can aid in therapeutic cardiac tissue regeneration.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-14197 (Browse shelf(Opens below)) Available

Cardiac disease is the main cause of death in men and women in México and the U.S.A. When heart muscle suffers an injury, i.e. cardiac infarction, the tissue dies and is replaced by a fibrotic scar that does not allow for normal organ function. To alleviate scar tissue, the objective of this work was to investigate and synthesize polyurethane ureas from polycaprolactone diol, methylene bis(4-cyclohexilisocyanate), and butanediamine with different hard segment contents, characterize them, and prove their biocompatibility by seeding SCA-1+/CD45- cardiac progenitor cells obtained from mice cardiospheres. Ultimately, this work aims to explore how polyurethane urea elastomers can aid in therapeutic cardiac tissue regeneration.

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