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Acid dissociation and metal complex formation constants of penicillamine, cysteine, and antiarthritic gold complexes at simulated biological conditions

Tipo de material: TextoTextoSeries ; Journal of Pharmaceutical Sciences, 68(4), p.426-432, 1979Trabajos contenidos:
  • Zucconi, T.D
  • Janauer, G.E
  • Donahe, S
  • Lewkowicz, C
Tema(s): Recursos en línea: Resumen: Ionization constants for acid functions of D-penicillamine, L-cysteine, thiomalic acid, and thioglucose were measured by pH titration at 37° and 0.15 M ionic strength. Chelate formation constants for these ligands with calcium(II), iron(III), and gold(I)were then determined under the same conditions chosen to approximate the in vivo situation. Only iron(III)formed both 1:1 and 1:2 chelates with D-penicillamine, L-cysteine, and thiomalate; calcium formed weak and gold strong 1:1 complexes with all ligands studied. Because of precipitate formation, the stability constants for the systems thioglucose-iron(III), D-penicillamine-gold(I), and L-cysteine-gold(l)had to be determined indirectly with thiomalic acid as the competing ligand. The in vivo fate of antiarthritic gold(I)compounds remained uncertain, but gold(I)chelates probably persist as such for extended periods.
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Ionization constants for acid functions of D-penicillamine, L-cysteine, thiomalic acid, and thioglucose were measured by pH titration at 37° and 0.15 M ionic strength. Chelate formation constants for these ligands with calcium(II), iron(III), and gold(I)were then determined under the same conditions chosen to approximate the in vivo situation. Only iron(III)formed both 1:1 and 1:2 chelates with D-penicillamine, L-cysteine, and thiomalate; calcium formed weak and gold strong 1:1 complexes with all ligands studied. Because of precipitate formation, the stability constants for the systems thioglucose-iron(III), D-penicillamine-gold(I), and L-cysteine-gold(l)had to be determined indirectly with thiomalic acid as the competing ligand. The in vivo fate of antiarthritic gold(I)compounds remained uncertain, but gold(I)chelates probably persist as such for extended periods.

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