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Five New Steroidal Saponins from Solanum chrysotrichum Leaves and Their Antimycotic Activity

Tipo de material: TextoTextoSeries ; Journal of Natural Products, 65, p.1815-1819, 2002Trabajos contenidos:
  • Zamilpa, A
  • Tortoriello, J
  • Navarro, V
  • Delgado, G
  • Alvarez, L
Recursos en línea: Resumen: Using bioactivity-directed isolation procedures, five new spirostan saponins and two sterol glycosides have been isolated from Solanum chrysotrichum leaves. The structure of these compounds was established based upon spectroscopic measurements, especially 1D and 2D NMR data of their peracetate derivatives. These compounds showed antimycotic activity. The most active compound is 6R-O-â-D-xylopyranosyl- (1f3)-â-D-quinovopyranosyl-(25R)-5R-spirostan-3â,23R-ol (2)(MIC )12.5, 12.5, 100, and 200 íg/mL against Trichophyton mentagrophytes, T. rubrum, Aspergillis niger, and Candida albicans, respectively).
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Using bioactivity-directed isolation procedures, five new spirostan saponins and two sterol glycosides have been isolated from Solanum chrysotrichum leaves. The structure of these compounds was established based upon spectroscopic measurements, especially 1D and 2D NMR data of their peracetate derivatives. These compounds showed antimycotic activity. The most active compound is 6R-O-â-D-xylopyranosyl- (1f3)-â-D-quinovopyranosyl-(25R)-5R-spirostan-3â,23R-ol (2)(MIC )12.5, 12.5, 100, and 200 íg/mL against Trichophyton mentagrophytes, T. rubrum, Aspergillis niger, and Candida albicans, respectively).

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