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Determination of Anti-Tumor Constitute Mollugin from Traditional Chinese Medicine Rubia cordifolia: Comparative Study of Classical and Microwave Extraction Techniques

Tipo de material: TextoTextoSeries ; Separation Science and Technology, 44(4), p.995-1006, 2009Trabajos contenidos:
  • Wenyan Ma
  • Yanbin Lu
  • Xiaojing Dai
  • Rui Liu
  • Ruilin Hu
  • Yuanjiang Pan
Tema(s): Recursos en línea: Resumen: Rubia cordifolia is a common traditional Chinese medicine (TCM)used for centuries for the treatment of cough, inflammation of the joints, uterine hemorrhage, and uteritis. Mollugin is a major active component present in R. cordifolia and recognized as a potential anti-tumor compound. In this work, a microwave-assisted extraction (MAE)method has been developed for extracting mollugin from R. cordifolia. Several variables that can potentially affect the extraction yield, namely extracting solvent, microwave power, extraction time, and solid-liquid ratio were optimized. The separation and quantitative determination of mollugin was carried out by HPLC with UV detection at 254 nm. Under appropriate MAE conditions, such as extraction time of 4 min, ethanol concentration of 70
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Rubia cordifolia is a common traditional Chinese medicine (TCM)used for centuries for the treatment of cough, inflammation of the joints, uterine hemorrhage, and uteritis. Mollugin is a major active component present in R. cordifolia and recognized as a potential anti-tumor compound. In this work, a microwave-assisted extraction (MAE)method has been developed for extracting mollugin from R. cordifolia. Several variables that can potentially affect the extraction yield, namely extracting solvent, microwave power, extraction time, and solid-liquid ratio were optimized. The separation and quantitative determination of mollugin was carried out by HPLC with UV detection at 254 nm. Under appropriate MAE conditions, such as extraction time of 4 min, ethanol concentration of 70

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