Function of alternative splicing
Tipo de material:
TextoSeries ; Gene, 344, p.1-20, 2005Trabajos contenidos: - Stamm, S
- Ben-Ari, S
- Rafalska, I
- Tang, Y
- Zhang, Z
- Toiber, D
- Thanaraj, T.A
- Thanaraj, T.A
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Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, which primarily regulates the amount of transcripts, alternative splicing changes the structure of transcripts and their encoded proteins. Together with nonsense-mediated decay (NMD), at least 25
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