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Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest

Tipo de material: TextoTextoSeries ; PhytoChemistry, 70(4), p.546-553, 2009Trabajos contenidos:
  • Allouche, N
  • Apel, C
  • Martin, M.T
  • Dumontet, V
  • Guéritte, F
  • Litaudon, M
Tema(s): Recursos en línea: Resumen: One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae)along with six known drimanes, isodrimanial, 1b-O-p-methoxy-E-cinnamoyl-bemadienolide, 7-ketoisodrimenin, drimenin, polygodial and 1b-E-cinnamoyl-6a-hydroxypolygodial. Their structures were elucidated through analysis of spectroscopic data. Drimane sesquiterpenoids with a dialdehyde function exhibited significant inhibitory activities in the in vitro cytotoxic assays against KB, HL60 and HCT116 cancer cell lines.
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One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae)along with six known drimanes, isodrimanial, 1b-O-p-methoxy-E-cinnamoyl-bemadienolide, 7-ketoisodrimenin, drimenin, polygodial and 1b-E-cinnamoyl-6a-hydroxypolygodial. Their structures were elucidated through analysis of spectroscopic data. Drimane sesquiterpenoids with a dialdehyde function exhibited significant inhibitory activities in the in vitro cytotoxic assays against KB, HL60 and HCT116 cancer cell lines.

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