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090			_aB-3657
245	1	0	_aTrichostatin A and vorinostat promote adipogenic differentiation through H3K9 acetylation and dimethylation
490	0		_vResearch in veterinary Science, 126, p.207-212, 2019
520	3		_aTo explore the effect of epigenetic modification on the differentiation of goat adipose-derived stem cells in vitro, we used two common epigenetic modification inhibitors, trichostatin A and vorinostat, to treat cashmere goat adipose-derived stem cells and induce adipocyte differentiation. The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG)transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. We conclude that adipocyte differentiation is regulated dynamically by different histone modifications. The areas of acetylation and demethylation changed by trichostatin A and vorinostat are the basis for further research on the mechanism of PPARG promoter to regulate adipocytes differentiation and provide research theroies for using adipose-derived stem cells as donor to produce transgenic animals to improve meat quality improvement.
650	1	4	_aACETYLATION
650	1	4	_aADIPOGENIC DIFFERENTIATION
650	1	4	_aADIPOSE-DERIVED STEM CELLS
650	1	4	_aDIMETHYLATION
650	1	4	_aGOAT
700	1	2	_aWang, X.
700	1	2	_aWang, Z.
700	1	2	_aWang, Q.
700	1	2	_aLiang, H.
700	1	2	_aLiu, D.
856	4	0	_uhttps://drive.google.com/file/d/1S-lPYqOR5vk2dkl2Ba4VZ1RR3w1u5pH2/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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