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245	1	0	_aMAPK-regulated transcription: a continuously variable gene switch?
490	0		_vNature Reviews Molecular Cell Biology , 3(1), p.30-40, 2001
520	3		_aSwitching mechanisms that control genes could be viewed either as stable binary switches, in which genes exist in 'on' or 'off' states; or as quantitative rheostat-like switches, in which the rate of transcription is continuously variable and coupled directly to the strength of intracellular signalling events. Here, we discuss the biological need for quantitative gene regulation and, using mitogen-activated protein kinase (MAPK)-controlled transcription as a model, assess the evidence for its existence and postulate mechanisms by which it might occur.
700	1	2	_aHazzalin, C.A.
700	1	2	_aMahadevan, L.C.
856	4	0	_uhttps://drive.google.com/file/d/157tkoynC5l9jfWk5F0xa2o1cLpXxmaVz/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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