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090			_aB-6085
245	1	0	_aThe Isolation of FOS-1, a Gene Encoding a Putative Two-Component Histidine Kinase from Aspergillus fumigatus
490	0		_vFungal Genetics and Biology , 31(1), p.55-67, 2000
520	3		_aIn fungi, two-component histidine kinases are involved in response mechanisms to extracellular changes in osmolarity, resistance to dicarboximide fungicides, and cell-wall assembly. In the human opportunistic fungus, Candida albicans, each of the three histidine kinases plays a role in virulence. Here, we identify, for the first time, a gene, FOS-1, from the human pathogenic fungus Aspergillus fumigatus that predicts a protein with homology to two-component histidine kinases. The predicted FOS-1 protein is highly homologous to bacterial and other fungal histidine kinases in several functional domains, but is divergent at the amino- and carboxy-termini. A mutant lacking the FOS-1 locus, ?FOS-1, did not exhibit a detectable defect in either hyphal growth or morphology when grown on solid or liquid medium. However, in liquid medium, conidiophore development of the ?FOS-1 mutant was delayed. Compared to wild type, the ?FOS-1 strain was neither osmotically sensitive nor sensitive or resistant to a number of nondicarboximide antifungal drugs, but was highly resistant to dicarboximide fungicides and resistant to novozym 234, suggesting that FOS-1p may play a role in the regulation of cell-wall assembly.
650	1	4	_aASPERGILLUS FUMIGATUS
650	1	4	_aTWO-COMPONENT HISTIDINE KINASE
650	1	4	_aDICARBOXIMIDE ANTIFUNGAL COMPOUNDS
650	1	4	_aFOS-1
650	1	4	_aCELL-WALL ASSEMBLY
700	1	2	_aPotta, G.B.
700	1	2	_aMillera, T.K.
700	1	2	_aBartletta, J.A.
700	1	2	_aPalasb, J.S.
700	1	2	_aSelitrennikoff, C.P.
856	4	0	_uhttps://drive.google.com/file/d/1U5UkZCRAIZhdi1N5kw7TdjfRP6l_WI_s/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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