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090			_aB-6086
245	1	0	_aCOS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor
490	0		_vMedical Mycology, 39, p.69-74, 2001
520	3		_aThe human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these histidine-kinase-encoding genes, COS-1, in C. albicans. Neither strain showed any growth defect in a number of liquid media nor increased resistance or sensitivity to a number of antifungal drugs. Importantly, we show that the COS-1 homozygous disruption strain had significantly reduced virulence in a systemic murine model of candidosis. Thus, COS-1 appears to be an in vivo virulence factor and may represent a novel target for the development of antifungal drugs.
700	1	2	_aSelitrennikoff, C.P.
700	1	2	_aAlex, L.
700	1	2	_aMiller, T. K.
700	1	2	_aClemons, K. V.
700	1	2	_aSimon, M. I.
700	1	2	_aStevens, D. A.
856	4	0	_uhttps://drive.google.com/file/d/1h1AkSy0F7u2AACQqWer9jQgBCiRWSwUM/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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