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245	1	0	_afos-1, a putative histidine kinase as a virulence factor systemic aspergillosis
490	0		_vMedical Mycology, 40(3), p.259-262, 2002
520	3		_aIn fungi, two-component histidine kinases have various functions including regulation of osmosensitivity, and of cell-wall assembly. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Recently, a putative histidine kinase, fos-1, has been isolated and partially characterized from Aspergillus fumigatus. Here we compare the virulence of a fos-1 deletion strain with that of the parental wild-type strain in a murine model of systemic aspergillosis. Our results show that the fos-1 deletion strain has significantly reduced virulence as compared with the parental wild-type strain. Thus, we propose that the fos-1 two-component histidine kinase is a virulence factor of A. fumigatus.
700	1	2	_aClemons, K. V.
700	1	2	_aMiller, T. K.
700	1	2	_aSelitrennikoff, C. P.
700	1	2	_aStevens, D. A.
856	4	0	_uhttps://drive.google.com/file/d/1E-6hOCPPr5YmOLu3i1PEOpByM503LYip/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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