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090			_aB-6187
245	1	0	_aInsight into the genome of Aspergillus fumigatus: analysis of a 922 kb region encompassing the nitrate assimilation gene cluster
490	0		_vFungal Genetics and Biology, 41(4), p.443-453, 2004
520	3		_aAspergillus fumigatus is the most ubiquitous opportunistic filamentous fungal pathogen of human. As an initial step toward sequencing the entire genome of A. fumigatus, which is estimated to be ~30 Mb in size, we have sequenced a 922 kb region, contained within 16 overlapping bacterial artificial chromosome (BAC)clones. Fifty-four percent of the DNA is predicted to be coding with 341 putative protein coding genes. Functional classification of the proteins showed the presence of a higher proportion of enzymes and membrane transporters when compared to those of Saccharomyces cerevisiae. In addition to the nitrate assimilation gene cluster, the quinate utilisation gene cluster is also present on this 922 kb genomic sequence. We observed large scale synteny between A. fumigatus and Aspergillus nidulans by comparing this sequence to the A. nidulans genetic map of linkage group VIII.
650	1	4	_aASPERGILLUS FUMIGATUS
650	1	4	_aGENE-CLUSTER
650	1	4	_aBAC-END SEQUENCING
650	1	4	_aGENOME
650	1	4	_aANNOTATION
650	1	4	_aCOMPARATIVE GENOMICS
650	1	4	_aSYNTENY
700	1	2	_aPain, A
700	1	2	_aWoodward, J.
700	1	2	_aQuail, M.A.
700	1	2	_aAnderson, M.J.
700	1	2	_aClark, R.
700	1	2	_aCollins, M.
700	1	2	_aFosker, N.
700	1	2	_aFosker, N.
700	1	2	_aHarris, D.
700	1	2	_aLarke, N.
856	4	0	_uhttps://drive.google.com/file/d/1TZ7y9obfOwdPhyER7cEY8DrDuY2jQpwY/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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