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245	1	0	_aIsolation of a Previously Unidentified Polysaccharide (MAR-10)from Hyssop officinalis That Exhibits Strong Activity Against Human Immunodeficiency Virus Type 1
490	0		_vBioChemical and Biophysical Research Communications, 210(1), p.145-151, 1995
520	3		_aA polysaccharide (MAR-10)was isolated from the aqueous extract of the plant Hyssop officinalis and examined for its activity against HIV-1 (SF strain)in HUT78 T cell line and primary cultures of peripheral blood mononuclear cells. MAR-10, in a concentration-dependent manner,inhibited HIV-1 replication as demonstrated by the inhibition of HIV-1 p24 antigen and syncytia formation. Furthermore, MAR-10 had no significant direct toxicity or effect on lymphocyte functions or CD4+ and CD8+ T cell counts. In addition, MAR-10 has broad spectrum anti-glycosidase activity. Our study demonstrates that MAR-10 contains strong anti-HIV-1 activity that may be useful in the treatment of patients with HIV-1 infection.
700	1	2	_aGollapudi, S.
700	1	2	_aSharma, H.A.
700	1	2	_aAggarwal, S.
700	1	2	_aByers, L.D.
700	1	2	_aEnsley, H.E.
700	1	2	_aGupta, S.
856	4	0	_uhttps://drive.google.com/file/d/1iTgTKqxqckgt3-4zDQuIUviLquz41GAk/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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