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040			_cCICY
090			_aB-6566
245	1	0	_aHigh-throughput RNAi in Caenorhabditis elegans: genome-wide screens and functional genomics
490	0		_vDifferentiation, 72(2-3), p.81-91, 2004
520	3		_aThe phenomenon of RNA-mediated interference (RNAi)was first discovered in the nematode Caenorhabditis elegans, in which introduction of double-stranded RNA causes specific inactivation of genes with corresponding sequences. Technical advances in RNAi methodology and the availability of the complete genome sequence have enabled the high-throughput, genome-wide RNAi analysis of this organism. Several groups have used large-scale RNAi to systematically examine every C. elegans gene for knock-down phenotypes, providing basal information to be mined in more detailed studies. Now, in addition to functional genomic RNAi analyses, high-throughput RNAi is also routinely used for rapid, genome-wide screens for genes involved in specific biological processes. The integration of high-throughput RNAi experiments with other large-scale data, such as DNA microarrays and protein-protein interaction maps, enhances the speed and reliability of such screens. The accumulation of RNAi phenotype data dramatically accelerates our understanding of this organism at the genetic level.
700	1	2	_aSugimoto, A.
856	4	0	_uhttps://drive.google.com/file/d/1Pf6Ep9D1MXdAhY69r1tUGqZmTUtKyO16/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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