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090			_aB-7145
245	1	0	_aIn vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalconein a solid human carcinoma xenograft model
490	0		_vCancer Chemother Pharmacol, 56(1), p.70-74, 2005
520	3		_aPreviously we have shown that 2¢,4¢-dihydroxy- 6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from the buds of Cleistocalyx operculatus, significantly inhibits the growth of human liver cancer SMMC-7721 cells and is able to induce apoptosis of SMMC-7721 cells in vitro. Here we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft mouse model using human liver cancer SMMC-7721 cells. The average tumor weights in the control group and in mice injected with 150 mg/kg DMC were 1.42±0.11 g and 0.59±0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated an aneuploid peak (representing 33.60±0.80
650	1	4	_aCLEISTOCALYX OPERCULATUS
650	1	4	_aFLAVONOIDS
650	1	4	_aTUMOR
650	1	4	_aACUTE TOXICITY
650	1	4	_aXENOGRAFT
700	1	2	_aYe, Ch.L.
700	1	2	_aLiu, J.W.
700	1	2	_aWei, D.Z.
700	1	2	_aLu, Y.H.
700	1	2	_aQian, F.
856	4	0	_uhttps://drive.google.com/file/d/13_g-qrqRpZ1rlfZqviOJoDqOddX--KvH/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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